Organometallic Compounds
Medchemexpress LLC M-PEG3-azide | 74654-06-1 | 98.0% | C7H15N3O3 | 500 MG
m-PEG3-azide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent containing an Azide group. This allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an Azide group
- Participates in CuAAc reactions with Alkyne groups
- Participates in SPAAC reactions with DBCO or BCN groups
Medchemexpress LLC Bis-PEG5-acid 10g | 439114-13-3 | 338.35 g/mol | C14H26O9 | 10 G
Bis-PEG5-acid is a polyethylene glycol (PEG) linker with two terminal carboxylic acid groups used to assemble PROTACs and other bifunctional molecules. The hydrophilic spacer increases aqueous solubility and provides flexible separation between ligands for conjugation chemistry.
- Two terminal carboxylic acid groups for conjugation.
- Hydrophilic PEG spacer improves solubility in aqueous media.
- Flexible linker suitable for PROTAC and bifunctional molecule assembly.
- Available in multiple package sizes including 10 G.
- Solid material with white to yellow appearance.
![Medchemexpress LLC Hydroxylamine, O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]- | 1306615-51-9 | MFCD28505530 | 95.0% | 234.25 g/mol | C8H18N4O4 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202088.png-250.jpg)
Medchemexpress LLC Hydroxylamine, O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]- | 1306615-51-9 | MFCD28505530 | 95.0% | 234.25 g/mol | C8H18N4O4 | 10 MG
Aminooxy-PEG3-azide is a PEG-based bifunctional linker containing an aminooxy (oxyamine) group and an azide group. It is used as a non-cleavable three-unit PEG spacer for antibody-drug conjugate (ADC) and PROTAC synthesis, and as an azide reagent for click chemistry reactions such as CuAAC and SPAAC.
- Bifunctional aminooxy and azide groups for oxime ligation and click chemistry.
- Non-cleavable three-unit PEG spacer suitable for ADC and PROTAC linker installation.
- Purity 95.0% and molecular weight 234.25 g/mol.
- Appearance colorless to light yellow liquid for easy handling.
- Storage: pure form -20°C (stable 3 years); in solvent -80°C (6 months) or -20°C (1 month).
- Available in small pack sizes, including 10 mg for small-scale synthesis.
Medchemexpress LLC 4,7,10-trioxa-3-siladodecan-12-ol, 2,2,3,3-tetramethyl- | 201037-95-8 | MFCD30471718 | ≥98.0% | 264.43 g/mol | C12H28O4Si | 250 MG
TBDMS-PEG3-OH is a tert-butyldimethylsilyl (TBDMS)-protected PEG3 alcohol used as a linker or spacer in organic synthesis, PROTAC construction, and drug-delivery conjugation. It provides a protected terminal alcohol for selective deprotection and coupling reactions.
- Provides a TBDMS-protected terminal alcohol for selective deprotection and coupling.
- Suitable as a PEG3 linker or spacer in medicinal chemistry and PROTAC synthesis.
- High purity (≥98%) and molecular weight 264.43 g/mol.
- Liquid, colorless to light yellow, convenient for solution-phase reactions.
- Recommended storage: pure form -20°C (long term) or 4°C (short term); in solvent store at -80°C.
Medchemexpress LLC Bromoacetamido-PEG3-NH-Boc | 1421933-39-2 | C15H29BrN2O6 | 5 G
Bromoacetamido-PEG3-NH-Boc is a PEG-based PROTAC linker.
- Can be used in the synthesis of PROTACs.
- PROTACs contain two different ligands connected by a linker.
- One ligand is for an E3 ubiquitin ligase and the other is for the target protein.
- PROTACs exploit the intracellular ubiquitin-proteasome system.
- Selectively degrade target proteins.
Medchemexpress LLC Azido-PEG5-triethoxysilane | 3025193-22-7 | MFCD31693730 | 95.0% | C22H46N4O9Si | 25 MG
Azido-PEG5-triethoxysilane is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, which allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Used in the synthesis of PROTACs.
- Functions as a click chemistry reagent.
- Contains an Azide group for copper-catalyzed azide-alkyne cycloaddition reactions.
- Can undergo strain-promoted alkyne-azide cycloaddition reactions.
- PROTACs enable selective degradation of target proteins via the intracellular ubiquitin-proteasome system.
Medchemexpress LLC THP-PEG5-OH | 146395-14-4 | 25 MG
THP-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also described as a reference compound.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Reference compound
Medchemexpress LLC NH2-PEG5-C6-Cl hydrochloride | 2241669-16-7 | 98.0% | 100 MG
NH2-PEG5-C6-Cl hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two different ligands connected by a linker
- One ligand binds to an E3 ubiquitin ligase
- The other ligand targets a specific protein
- Leverages the intracellular ubiquitin-proteasome system
- For selective degradation of target proteins
Medchemexpress LLC BnO-PEG5-OH | 57671-28-0 | 98.6% | 328.40 g/mol | C17H28O6 | 10 G
BnO-PEG5-OH is a polyethylene glycol (PEG)-based PROTAC linker used to connect ligands in proteolysis targeting chimera (PROTAC) synthesis, providing spacer functionality and flexibility to aid target engagement and E3 ligase recruitment.
- Polyethylene glycol spacer with five ethylene glycol units.
- High purity suitable for research applications.
- Liquid, colorless to light yellow, density ≈ 1.10 g/cm3.
- Stable under recommended storage conditions for pure material and in solvent.
- Available in common laboratory pack sizes, including 10 g.
![Medchemexpress LLC 2-[2-(2-azidoethoxy)ethoxy]ethanol | 86520-52-7 | MFCD09753542 | 98.2% | 175.19 g/mol | C6H13N3O3 | 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000300804.png-250.jpg)
Medchemexpress LLC 2-[2-(2-azidoethoxy)ethoxy]ethanol | 86520-52-7 | MFCD09753542 | 98.2% | 175.19 g/mol | C6H13N3O3 | 1 G
Azido-PEG3-alcohol (2-[2-(2-azidoethoxy)ethoxy]ethanol, CAS 86520-52-7) is an azide-terminated PEG3 linker designed for click chemistry conjugations and PROTAC linker assembly. It contains a terminal hydroxyl for further functionalization and an azide group compatible with both copper-catalyzed and strain-promoted azide-alkyne cycloadditions.
- Azide functional group enables CuAAC and SPAAC conjugations.
- PEG3 spacer increases aqueous solubility and flexibility.
- Small molecular weight (175.19 g/mol) minimizes steric hindrance.
- High purity suitable for synthetic applications and conjugation reactions.
- Terminal hydroxyl allows additional derivatization or coupling.
Medchemexpress LLC Peg3-C4-Obn | 2381196-79-6 | 99.3% | 25 MG
PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. It is utilized in the synthesis of a potent SKG3 degrader based on PROTAC.
- Liquid appearance
- Colorless to light yellow
- Purity of 99.3%
- Molecular weight of 296.40
- Molecular formula C17H28O4
- Used as a PROTAC linker
- Soluble in DMSO: ≥ 100 mg/mL
Medchemexpress LLC I-PEG5-OH 250mg
I-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Medchemexpress LLC 4,7,10-trioxa-3-siladodecan-12-ol, 2,2,3,3-tetramethyl- | 201037-95-8 | ≥98.0% | 264.43 g·mol-1 | C12H28O4Si | 500 MG
TBDMS-PEG3-OH is a tert-butyldimethylsilyl (TBDMS)-protected PEG3 hydroxy derivative used as a linker or spacer in drug delivery and conjugation chemistry. It has formula C12H28O4Si, a molecular weight of 264.43 g·mol-1, and is provided at high purity for research use.
- used as a PEG linker for conjugation and spacer chemistry.
- TBDMS protection enables selective silyl-deprotection strategies.
- high purity (≥98.0%) suitable for research applications.
- available in multiple pack sizes for small- to medium-scale synthesis.
Medchemexpress LLC Pomalidomide-PEG3-azide | 2267306-15-8 | MFCD32198606 | >98.0% | C21H24N6O8 | 10MG
Pomalidomide-PEG3-azide is an E3 ligase ligand-linker conjugate used as a building block in PROTAC synthesis and bioconjugation. It pairs a pomalidomide-derived cereblon-binding moiety with a three-unit polyethylene glycol linker terminated by an azide, enabling modular assembly of degrader molecules and efficient azide-alkyne click chemistry.
- Azide functional group for click chemistry conjugation
- PEG3 linker provides flexibility and solubility
- Cereblon-binding ligand supports targeted protein degradation
- High reported purity for reliable synthesis
- Suitable for PROTAC assembly and chemical probe development